Endogenous opioids: opposing stress with a cost
نویسندگان
چکیده
منابع مشابه
Endogenous opioids: opposing stress with a cost
The stress response is characterized by the coordinated engagement of central and peripheral neural systems in response to life-threatening challenges. It has been conserved through evolution and is essential for survival. However, the frequent or continual elicitation of the stress response by repeated or chronic stress, respectively, results in the dysfunction of stress response circuits, ult...
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Our dynamic environment regularly exposes us to potentially life-threatening challenges or stressors. To answer these challenges and maintain homeostasis, the stress response, an innate coordinated engagement of central and peripheral neural systems is initiated. Although essential for survival, the inappropriate initiation of the stress response or its continuation after the stressor is termin...
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In recent years, research has shown the involvement of free radicals in the development of the pain that accompanies many pathological conditions. In the treatment of acute and chronic pain, the most effective therapies are natural and synthetic opioid alkaloids. Their metabolism in itself may contribute to the formation of free radicals and thus affect body system load and the perception of pa...
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Endogenous opioid peptides and their receptors are involved in the modulation of a variety of behavioral functions because of their relatively diffuse distribution in the CNS. Recent research suggests that endogenous opioids modulate incentive processes. Incentives are environmental resources that motivate the organism to behave. Incentive motivation is activated by expectancies which, in turn,...
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We describe two studies designed to elucidate the role of endogenous opioids in blood pressure control in humans. In the first study, nine normal subjects received infusions of DAMME (a metenkephalin analog), naloxone, or saline, and blood pressure, heart rate, and plasma norepinephrine concentration were determined supine and following 5 minutes of 70 degrees head-up tilt at intervals for 6 ho...
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ژورنال
عنوان ژورنال: F1000Prime Reports
سال: 2015
ISSN: 2051-7599
DOI: 10.12703/p7-58